Abstract and Introduction
In 2019, 65.8 million U.S. adults reported past-month binge drinking and 35.8 million reported illicit drug use or prescription pain reliever misuse during the past month; 20.4 million met diagnostic criteria for a substance use disorder during the past year. Approximately 81,000 persons died of a drug overdose* during May 2019–May 2020; excessive alcohol use contributes to an estimated 95,000 deaths per year. Persons with a substance use disorder are at elevated risk for overdose and associated harms. To examine the prevalence of past 30-day substance use patterns and the severity of problems experienced across seven biopsychosocial domains (alcohol, drug, employment, family, legal, medical, and psychiatric), CDC used 2019 data from the National Addictions Vigilance Intervention and Prevention Program (NAVIPPRO) Addiction Severity Index-Multimedia Version (ASI-MV) tool; these data are collected from adults aged ≥18 years who seek substance use treatment in the United States. Alcohol was the most commonly reported substance used during the past 30 days (35.8%), followed by cannabis (24.9%), prescription opioids (misuse) (18.5%), illicit stimulants (14.0%), heroin (10.2%), prescription sedatives or tranquilizers (misuse) (8.5%), cocaine (7.4%), illicit fentanyl (4.9%), and prescription stimulants (misuse) (1.8%).† Polysubstance use (use of two or more substances) during the past 30 days was reported by 32.6% of respondents. Among the biopsychosocial domains measured, 45.4% of assessments reported more severe problems with drugs; others reported psychiatric (35.2%), legal (28.8%), medical (27.4%), employment (25.0%), alcohol (24.2%), and family problems (22.8%). These findings highlight the complex nature of substance use in the United States, the interplay between substance use and mental illness, and the complex challenges that persons with substance use disorder face when seeking treatment. Actions to enhance comprehensive substance use programs that incorporate polysubstance use and co-occurring mental health problems into strategies for prevention, treatment, and response are needed, as is expanded linkage to services. CDC provides data and resources to equip and inform states, territories, and local jurisdictions to help improve opioid prescribing practices, improve linkage to care for the treatment of opioid use disorder, and prevent and reverse overdoses.§
NAVIPPRO ASI-MV tool is a validated self-administered, computerized, structured clinical assessment tool administered upon admission to a substance use treatment facility; the questionnaire is designed to assess each of seven biopsychosocial domains that might affect a respondent's substance use. A rating is calculated for each domain, indicating the severity of the problem and the need for treatment. The ASI-MV also collects detailed information on lifetime and past 30-day use of tobacco, alcohol, and illicit drugs, as well as use and misuse of prescription drugs.
Using 2019 NAVIPPRO data, CDC assessed the prevalence of past 30-day use overall and by demographic factors (sex, age, race and ethnicity, education, employment status, urban-rural residence, and U.S. Census Bureau region¶ of treatment site) for the following substances: alcohol, cannabis, cocaine, illicit stimulants, heroin, illicit fentanyl, prescription opioids (misuse), prescription stimulants (misuse), and prescription sedatives or tranquilizers (misuse). The prevalence of moderate to extremely severe problems** was calculated for each of the seven biopsychosocial domains overall and by demographic characteristics. P-values were calculated using Pearson's chi-square tests to compare the distribution of demographic characteristics among those who reported past 30-day use of a given substance with those who did not report past 30-day use of that substance; those with a severity score of 4–9 (more severe) in each of the biopsychosocial domains were compared with those with a severity of 0–3 (less severe) in that domain. Respondents with unknown or no response were excluded. P-values <0.05 were considered statistically significant. The prevalences of polysubstance use during the past 30-days and substance combinations were analyzed. All analyses were conducted using SAS (version 7.1; SAS Institute). This activity was reviewed by CDC and was conducted consistent with applicable federal law and CDC policy.††
Data from 399 treatment centers in 37 states contributed to the 2019 ASI-MV. Although the centers are primarily substance use treatment centers, other sites, such as driving while intoxicated centers, probation offices, or any site using the ASI-MV tool that agrees to share aggregate assessment data might also be included. Among the 49,138 ASI-MV adults assessed for substance use treatment planning, the majority were men (63.4%), non-Hispanic White persons (65.8%), had a high school education or less (65.4%), and were assessed in metropolitan areas (66.6%) and in the South U.S. Census Bureau region (62.2%) (Table 1).
Alcohol was the substance most commonly reported (35.8%), followed by cannabis (24.9%), prescription opioid misuse (18.5%), illicit stimulants (14.0%), heroin (10.2%), misuse of prescription sedatives or tranquilizers (8.5%), cocaine (7.4%), illicit fentanyl (4.9%), and prescription stimulant misuse (1.8%). Compared with men, women reported higher use of all substances except alcohol. Comparing the prevalence of past 30-day substance use reported in each of the four U.S. Census Bureau regions, the prevalence of heroin, cocaine, illicit fentanyl, and prescription sedative use was highest at Northeast treatment sites, whereas the prevalence of illicit stimulant use was highest at Midwest treatment sites. Among all adults assessed, 32.6% reported use of two or more substances during the past 30 days; the most common polysubstance combinations were alcohol and cannabis (17.2%), followed by cannabis and illicit stimulants (3.7%), and alcohol and prescription opioids (3.4%) (Figure).
Most common substance combinations reported among past 30-day polysubstance* users aged ≥18 years (N = 16,033) — United States,† 2019
Source: National Addictions Vigilance Intervention and Prevention Program, Addiction Severity Index-Multimedia Version tool.
Abbreviations: ASI-MV = Addiction Severity Index-Multimedia Version; Rx = prescription.
*Polysubstance use includes past 30-day use (or prescription medication misuse) of at least two of the following: alcohol, cannabis, heroin, illicit fentanyl, prescription opioids (misuse), barbiturates, prescription sedatives or tranquilizers, cocaine, prescription stimulants (misuse), illicit stimulants (i.e., illegal amphetamines including crank, ice, or methamphetamines; this group does not include cocaine), hallucinogens, inhalants, ecstasy, gamma hydroxybutyrate, ketamine, synthetic cannabinoids (e.g., K2), bath salts, rohypnol, over-the-counter medications, and other unspecified drugs. The remaining unique substance combinations each represented <1% of all combinations among assessments reporting use of two or more substances during the past 30 days. Polysubstance use as displayed in this figure does not necessarily represent use of substances simultaneously.
†Data represent 32.6% of all 2019 adult ASI-MV assessments that reported polysubstance use (i.e., using two or more substances) during the past 30 days.
Among the biopsychosocial domain problems measured, 45.4% of adults assessed reported more severe problems with drugs, followed by psychiatric (35.2%), legal (28.8%), medical (27.4%), employment (25.0%), alcohol (24.2%), and family problems (22.8%) (Table 2). Compared with men, women reported more severe problems for all domains except alcohol. Adults aged 25–34 years reported more severe problems with drugs (49.9%) and those aged 55–64 years reported more severe problems with alcohol (41.1%). Approximately two thirds (67.4%) of unemployed adults assessed experienced more severe drug problems, and retired or disabled adults experienced more severe psychiatric (53.3%) and medical (59.6%) problems.
Morbidity and Mortality Weekly Report. 2022;71(23):749-756. © 2022 Centers for Disease Control and Prevention (CDC)